tert-butyl 2 4-dioxopiperidine-1-carboxylate（CAS# 845267-78-9)

Formulae hypotheticae	C10H15NO4
Molar Mass	213.23
Densitas	1.199
Boling Point	373.8±35.0 °C (Predicta)
Flash Point	179.9°C
Vapor Pressura	8.72E-06mmHg at 25°C
pKa	10.67±0.20 (Praedicta)
Repono Condition	Tene in caliginoso loco, signatus in sicco, cella Temperature
Index refractivus	1.493
MDL	MCD10566071

Product Detail

Periculum Codes	20/21/22 - Inspiratione noxia, in contactu cum cute et absorpta.
Salus Descriptio	S23 — Vaporem non spiro. S24/25 – Fuge contactum cum cute et oculis.
WGK Germania	3
HS Code*	29337900

Usus	2, 4-dipiperidon-1-formatum tert-butyl formatum est synthesis phenoxymethyl-dihydrothiazolopyridonis derivatorum Reactants in producto, ut structurae positivae selectivae modulatoris (PAM) metabolisi glutamati 5(mGlu5) receptoris.
application	2, 4-dioperidone-1-tert-butylo formata principaliter adhibetur ut media organica et media pharmaceutica, et adhiberi potest in inquisitione laboratoria et processu evolutionis et processu chemico et synthesi medicina.
praeparatio	gradus a: adde EDCI (191.7g) ad DMF(400mL) solutionem 3-(tert-butoxycarbonylamini) acidum propionicum (189.2g,1.0mol), acidum meldamicum (144.1g,1.0mol) et DMAP (135.0g,1.1mol. ) Balneum glaciei refrigeratum, 1.0mol). Reactants inde pernoctare in cella temperie commota sunt. Reactio extincta est cum 200mL H2O. Mixtio inde ad H2O (2.0L) sub motu mechanica addita est. Obtenta solida percolata est et aqua abluta ad pH 7 ad obtinendum productum (283g,90% cede). Gradus B: Solutio 3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl) -3-oxopropylcarbamatum tert-butyl ester (100g,317.46mmol) in toluene (1500mL) in C ° C ad IV horas calescit. Reactants refrigerantur ad cella temperies et coacta sub pressura reducta ad rudimentum obtinendum. Productum (56g,83% cedit) ab MTBE-molendo purgatum est.